The Wet AMD market growth is driven by factors like increase in the prevalence of Wet AMD, investments in research and development, entry of emerging therapies during the study period 2019-2032.
The Wet AMD market report also offers comprehensive insights into the Wet AMD market size, share, Wet AMD epidemiology, emerging therapies, market drivers and barriers, ongoing clinical trials, key collaboration in the space, market uptake by key therapies and companies actively pushing Wet AMD market size growth forward.
Some of the key highlights from the Wet AMD Market Insights Report:
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Wet AMD Overview
Age-related macular degeneration (AMD) is a multifactorial ocular disease that affects the maculae due to late-onset progressive neurodegeneration and dysfunction of photoreceptors and retinal pigment epithelium (RPE). Majorly, there are two types of AMD: dry (atrophic) and wet (neovascular or exudative). Most AMD starts as the dry type, and in 10–20% of individuals, it progresses to the wet type. The dry (atrophic) type affects approximately 80–90% of individuals with AMD. Its cause is unknown, it tends to progress more slowly than the wet type, and there is no approved treatment or cure. In dry age-related macular degeneration, small white or yellowish deposits, called drusen, form on the retina beneath the macula, causing it to deteriorate or degenerate over time. It accounts for about 80–90% of cases. The complaints of a patient with wet AMD may vary from metamorphopsia, central or paracentral scotoma, to a sudden, nonspecific reduction in central vision. Peripheral vision and color vision are generally unaffected; however, the patient may become legally blind (< 20/200 vision) in the affected eye, particularly if AMD is not treated. Central vision loss can progress over weeks, even days, in a more rapid fashion compared with dry AMD. Patients with advanced late AMD can have geographic atrophy, neovascular AMD, features of both, or disciform scarring, which is the end-stage result of neovascular AMD.
Rapid vision loss, usually over days to weeks, is more typical of wet AMD. Age-related macular degeneration is defined by fundus examination, but the diagnosis of AMD is typically based on age, clinical findings through various tests like Color fundus photography, Fluorescein angiography and/or Optical coherence tomography. Color photography and fluorescein angiography are done when findings suggest wet AMD. The goals of wet AMD treatment are to slow progression, preserve existing vision, and reverse vision loss if possible. Management of Wet AMD is done through anti-VEGF medications, photocoagulation, and /or photodynamic therapy. The choice of other treatments depends on the size, location, and type of neovascularization. Anti-VEGF medications are the most effective and most common treatment for wet AMD. Patients with unilateral wAMD should take the daily nutritional supplements that are recommended for dry AMD to reduce the risk of AMD-induced vision loss in the other eye. Low vision rehabilitation can also be an effective part of a wet AMD treatment plan.
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Recent Breakthrough in the Wet AMD Market:
4DMT completes enrollment of Phase 2 PRISM clinical trial for intravitreal 4D-150 in patients diagnosed with Wet AMD: 4D Molecular Therapeutics this week announced that it has completed enrollment of the Phase 2 Dose Expansion stage of the PRISM clinical trial for patients with wet age-related macular degeneration (wet AMD) over approximately two quarters and that no significant 4D-150 safety events or inflammation have been reported to date.
Wet AMD Epidemiology Segmentation
DelveInsight’s Wet AMD market report is prepared on the basis of an epidemiology model. It offers comprehensive insights to the Wet AMD historical patient pools and forecasted Wet AMD patients. The report provides in-depth data of various subtypes and for the same epidemiology is segmented further. The Wet AMD Market report proffers epidemiological analysis for the study period 2019-32 in the 7MM segmented into:
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Wet AMD Treatment Market
The Wet AMD market outlook of the report helps to build a detailed comprehension of the historic, current, and forecasted Wet AMD market trends by analyzing the impact of current Wet AMD therapies on the market, unmet needs, drivers and barriers, and demand for better technology.
This segment gives a thorough detail of Wet AMD market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated Wet AMD market data are presented with relevant tables and graphs to give a clear view of the market at first sight.
According to DelveInsight, the Wet AMD market in 7MM is expected to witness a major change in the study period 2019-2032.
Wet AMD Emerging Therapy Assessment
Abicipar pegol: Molecular Partners
Abicipar pegol is a long-acting anti-VEGF therapeutic candidate, which was invented by Molecular Partners and initially licensed to Allergan in 2011. The program has been through two positive Phase III studies, CEDAR and SEQUOIA, which supported the non-inferior efficacy of the Abicipar quarterly dosing regimen to maintain vision gains with more than 50 percent fewer injections versus ranibizumab (13 vs. 6) dosed monthly in the first year. In June 2020, a Complete Response Letter was issued for the Biologics License Application for Abicipar pegol, indicating that the rate of intraocular inflammation observed following administration of Abicipar pegol resulted in an unfavorable benefit-risk ratio in the treatment of nAMD (AMD), and that additional work would be required to demonstrate a lower rate of ocular inflammation than what was previously seen in the Phase III studies. In 2021, Molecular Partners regained global rights to Abicipar from AbbVie and is determining appropriate next steps for the program.
SOK583A1: Sandoz
Aflibercept binds and inhibits ocular VEGF-A and prevents abnormal growth of blood vessels in the choroid, impacting visual function. It improves visual acuity in patients with neovascular retinal diseases like nAMD, DME, and RVO. SOK583A1 is a biosimilar of Aflibercept (Eylea). It is currently in the Phase III stage of development for the treatment of wAMD and is being developed by Sandoz.
BA9101 (LY09004): Shandong Boan Biotechnology Co. Ltd.
BA9101 (LY09004), a biosimilar for Eylea, is a recombinant human vascular endothelial growth factor receptor-antibody fusion protein ophthalmic injection, indicated for neovascular (wet) age-related macular degeneration (AMD), macular edema following retinal vein occlusion (RVO), diabetic macular edema (DME) and diabetic retinopathy (DR) in patients with diabetic macular edema, and visual impairment due to pathological myopia secondary to choroidal neovascularization(PM-CNV). As a soluble decoy receptor, LY09004 can bind to cytokines such as VEGF-A, VEGF-B and P1GF, inhibit the downstream signaling pathway of VEGFR, inhibit neovascularization, and reduce vascular permeability, thereby treating pathological neovascularization of the retina and choroid eye diseases.
ADVM-022: Adverum Biotechnologies
ADVM-022 is a recombinant, replication-deficient adeno virus-associated (AAV) gene therapy. ADVM-022 utilizes a propriety vector capsid, AAV.7m8, carrying an aflibercept coding sequence under the control of a proprietary expression cassette. ADVM-022 (AAV.7m8-aflibercept) is administered as a single, in-office intravitreal (IVT) injection, designed to deliver long-term efficacy and reduce the burden of frequent anti-VEGF injections, optimize patient compliance and improve vision outcomes for patients with wet AMD and DME. The therapeutic candidate is in Phase II clinical studies for wet AMD.
Wet AMD Key Companies
For more information, visit Wet AMD Market Analysis, Patient Pool, and Emerging Therapies
Scope of the Wet AMD Market Report:
Key Questions Answered in the Wet AMD Market Report 2032:
Table of Contents:
1 Wet AMD Market Key Comprehensive Insights
2 Wet AMD Market Report Introduction
3 Competitive Intelligence Analysis for Wet AMD
4 Wet AMD Market Analysis Overview at a Glance
5 Executive Summary of Wet AMD
6 Wet AMD Epidemiology and Market Methodology
7 Wet AMD Epidemiology and Patient Population
8 Wet AMD Patient Journey
9 Wet AMD Treatment Algorithm, Wet AMD Current Treatment, and Medical Practices
10 Key Endpoints in Wet AMD Clinical Trials
11 Wet AMD Marketed Therapies
12 Wet AMD Emerging Therapies
13 Wet AMD: 7 Major Market Analysis
14 Attribute analysis
15 Access and Reimbursement Overview of Wet AMD
16 Wet AMD Market Key Opinion Leaders Reviews
18 Wet AMD Market Drivers
19 Wet AMD Market Barriers
20 SWOT Analysis
21 Disclaimer
22 DelveInsight Capabilities
23 About DelveInsight
Related Reports:
Wet AMD Epidemiology 2032
DelveInsight’s “Wet AMD – Epidemiology Forecast to 2032” report delivers an in-depth understanding of the disease, historical and forecasted Wet AMD epidemiology in the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.
Wet AMD Pipeline 2023
“Wet AMD Pipeline Insights, 2023” report by DelveInsight outlines comprehensive insights of present clinical development scenarios and growth prospects across the Wet AMD market. A detailed picture of the Wet AMD pipeline landscape is provided, which includes the disease overview and Wet AMD treatment guidelines.
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