Creative Biogene Develops One-stop Solutions for CircRNA Services to Accelerate Biomarker Discovery and Drug Development

August 12 16:03 2021
Creative Biogene develops one-stop solutions for circRNA services to accelerate the full scope of biotechnology needs of early drug discovery and drug development.

New York, USA – August 12, 2021 – Creative Biogene, one of the world’s leading biotechnology providers, is dedicated to developing high quality products and services to support the research in the field of basic life sciences research, biomedical development, industrial synthetic application and preclinical drug discovery. Recently, Creative Biogene develops one-stop solutions for circRNA services to accelerate the full scope of biotechnology needs of early drug discovery and drug development.

The circRNA service provided by Creative Biogene is usually only used for research purposes and not for clinical diagnosis. In order to discover and identify disease-related circRNAs, Creative Biogene uses circRNA sequencing or circRNA microarrays to detect genome-wide circRNA expression. Generally, multiple circRNA prediction algorithms are run to minimize the number of false positives and ensure the accuracy of the results.

For strict circRNA analysis methods, northern blot and RT-qPCR can be used to comprehensively characterize the expression level of candidate circRNA. Fluorescence in situ hybridization (FISH) is used to provide information about the location of a specific circRNA. In addition, Creative Biogene also provides circRNA suppression and overexpression services to assist customers in regulating the expression of circRNA. This may provide stronger evidence for revealing the function of circRNA in cancer cell proliferation and apoptosis.

Creative Biogene utilizes a variety of methods to explore the detailed binding sites of circRNA-miRNA and circRNA-RBP (RNA binding protein) interactions, including RNA immunoprecipitation (RIP) combined with luciferase reporter gene detection, RIP subsequent sequencing, and RNA pull down combined with mass spectroscopy.

Creative Biogene has developed a complete workflow for circRNA-miRNA or circRNA-RNA banded protein (RBP) interaction analysis and enhanced it with the latest technology. The high-quality circRNA interaction analysis service covers from target miRNA discovery to confirmation and interaction protein screening to verification.

Creative Biogene uses a dual luciferase reporter gene detection system to verify the sponge function of circRNA and detect target miRNA. This sensitive and effective detection method is suitable for most cell types. In order to analyze the interaction between circRNA and RNA band proteins, Creative Biogene has established a powerful interaction analysis system based on RNA pull-down analysis and RNA immunoprecipitation (RIP) technology. Its excellent interaction analysis system can be effective Screen and verify band proteins to expedite research plans.

“As a leading biotechnology company with the expertise and capabilities to provide global customers with circRNA services, Creative Biogene is always dedicated to offering professional support to satisfy customized needs.” said Marcia Brady, she also added, “we rely on sophisticated equipment, advanced technology and experienced staff to provide you with the most affordable and high-quality services, and ensure your satisfaction in a timely and professional manner.”

About Creative Biogene

Creative Biogene, as a top-of-its-kind company who holds a leading position and is committed to accelerating the development of human science through biotechnology, offering innovative technologies, products, unique tools and services for research discoveries and product development. With more than 10 years of experience and in-house experts, Creative Biogene has become a well-recognized industry leader to support researchers worldwide.

Media Contact
Company Name: Creative Biogene
Contact Person: Marcia Brady
Email: Send Email
Phone: 1-631-386-8241
Country: United States